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lacticaseibacillus paracasei SINEFREE
- Development stage
- Unknown
- Lead developer
- Shanghai Children's Medical Center
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lacticaseibacillus paracasei SINEFREE is a specific probiotic strain investigated as a live biotherapeutic for the treatment of pediatric allergic rhinitis. Developed by researchers at the Shanghai Children's Medical Center, this strain is administered orally as an adjunctive therapy alongside standard treatments such as intranasal corticosteroids and oral antihistamines. The drug functions by modulating the host immune system and the gut-lung axis, specifically aiming to balance Th1 and Th2 immune responses and alter the gut microbiota composition to alleviate symptoms of perennial moderate-to-severe allergic rhinitis in children. Clinical trials evaluate its efficacy based on symptom scores, quality of life metrics, and various immune and microbiome biomarkers.
- Brand names
- SINEFREE
- Other names
- Lacticaseibacillus paracasei SINEFREEL. paracasei SINEFREE
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