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lacticaseibacillus rhamnosus HM126
- Development stage
- Preclinical
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lacticaseibacillus rhamnosus HM126 is a probiotic bacterial strain isolated from healthy human breast milk, currently under investigation for the treatment of allergic and inflammatory disorders, including atopic dermatitis and allergic rhinitis. As a live biotherapeutic product, it functions by modulating the gut-skin and gut-respiratory axes. The strain helps maintain the balance between type 1 (Th1) and type 2 (Th2) immune responses, leading to a reduction in inflammatory cytokines such as interleukin-4 (IL-4) and a decrease in immunoglobulin E (IgE) levels. Preclinical studies have demonstrated its ability to reshape gut microbiota composition and metabolites, resulting in reduced scratching frequency and skin lesion severity in atopic dermatitis models, as well as alleviation of nasal symptoms in allergic rhinitis.
- Other names
- L. rhamnosus HM126
02
Targets
HCAR2 (Hydroxycarboxylic acid receptor 2)FFAR2HDAC (HDAC family)FFAR3 (Free fatty acid receptor 3)PRR (Pattern recognition receptors)
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