Drug intelligence / Profile preview

Lacticaseibacillus rhamnosus LR110

Development stage
Preclinical
Lead developer
Nordic Biotic
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral, Intravaginal
01

Overview

Lacticaseibacillus rhamnosus LR110 (DSM 33794) is a gram-positive, probiotic bacterial strain isolated from human feces and is part of the NORDBIOTIC™ strain collection developed by Nordic Biotic. [1] The active ingredient is the live bacterial strain itself. This strain has been investigated in a clinical setting as part of a multi-strain probiotic formulation (NORDBIOTIC™) for the treatment of symptomatic acute respiratory tract infections, including COVID-19. Genomic analysis of the strain has identified genes associated with thiamine salvage, lactose metabolism, putrescine biosynthesis, and bacteriocin production, which suggest potential therapeutic applications in managing conditions such as inflammatory diseases, obesity, and allergies.

Other names
L. rhamnosus LR110Lactobacillus rhamnosus LR110
02

Targets

Shigella spp. (Shigella species)AHR (Aryl hydrocarbon receptor)

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