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Lacticaseibacillus rhamnosus LR607
- Development stage
- Unknown
- Lead developer
- Southern Medical University Zhujiang Hospital
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lacticaseibacillus rhamnosus LR607 is a specific probiotic strain being investigated for its potential to modulate the gut microbiome and enhance the efficacy of cancer treatments. In the context of non-small cell lung cancer (NSCLC), it is being evaluated in a Phase 2 clinical trial as an oral supplement to neoadjuvant chemoimmunotherapy (immune checkpoint inhibitors plus platinum-based chemotherapy). The rationale is that specific probiotic strains can influence systemic immune responses and the tumor microenvironment via the gut-lung axis, potentially improving pathological complete response rates and reducing treatment-related toxicities.
- Other names
- Lacticaseibacillus rhamnosus LR607L. rhamnosus LR607
02
Targets
NOD2 (Nucleotide-binding oligomerization domain-containing protein 2)
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