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lactiplantibacillus plantarum LRCC5195
- Development stage
- Preclinical
- Lead developer
- LOTTE BIOLOGICS
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lactiplantibacillus plantarum LRCC5195 is a specific bacterial strain, often utilized in the form of paraprobiotics (heat-killed bacteria, designated LP5195-P), developed for the treatment of atopic dermatitis (AD). The strain functions by modulating the gut microbiota, increasing microbial diversity, and significantly altering the levels of short-chain fatty acids (SCFAs). These microbiome-driven changes lead to systemic immune regulation, characterized by the downregulation of Th2 and Treg-related gene expression in both the skin and the ileum. Additionally, LRCC5195 demonstrates inhibitory effects on histamine release and β-hexosaminidase activity, thereby alleviating clinical symptoms of dermatitis such as edema and erythema. It is primarily developed by the Lotte R&D Center.
- Other names
- Lactobacillus plantarum LRCC5195
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