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Lactiplantibacillus plantarum Probio87
- Development stage
- Unknown
- Lead developer
- Universiti Sains Malaysia
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lactiplantibacillus plantarum Probio87 is a specific probiotic strain developed and studied by Universiti Sains Malaysia. It is being investigated for its therapeutic potential in managing Human Papillomavirus (HPV) infections. In a randomized, double-blind, placebo-controlled clinical trial (NCT05316064), oral administration of L. plantarum Probio87 at a dose of 9 log CFU/day for 12 weeks was shown to significantly reduce vaginal HPV abundance. [6] The proposed mechanism involves the modulation of both the gut and vaginal microbiome, leading to an increase in beneficial Lactobacillus species and a decrease in pathogenic microbes. [5, 8] This modulation is believed to enhance local immunity, reduce inflammation, and improve the overall quality of life for HPV-positive women. [6]
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