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Lactobacillus acidophilus 821-3
- Development stage
- Unknown
- Lead developer
- University of Tartu
- Modality
- Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lactobacillus acidophilus 821-3 is a specific probiotic bacterial strain investigated for its potential application in biodefense. Developed by researchers at the University of Tartu with support from the Estonian Science Foundation, this strain was evaluated in a Phase 1 clinical trial (NCT00122408) to determine its safety, oral tolerability, and ability to persist within the human gastrointestinal tract. The therapeutic concept involves using the strain to enhance mucosal immunity or provide a biological barrier against bioterrorism agents, such as *Bacillus anthracis*. As a live biotherapeutic product, it aims to modulate the host's immune response and maintain a healthy microflora, thereby offering a form of passive or innate protection against pathogenic challenges.
- Other names
- L. acidophilus 821-3
02
Targets
SLC superfamily (Solute carrier superfamily)
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