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lactobacillus acidophilus NCFM
- Development stage
- Phase 2
- Lead developer
- DuPont
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral, Intravaginal
01
Overview
lactobacillus acidophilus NCFM is a specific probiotic bacterial strain of *Lactobacillus acidophilus* developed and studied by Danisco for immunomodulatory and gastrointestinal applications. It has been evaluated as an orally administered single-strain probiotic in human studies including pediatric birch pollen allergy, and has also been studied in atopic dermatitis and other settings, sometimes alongside other probiotic strains. Its therapeutic rationale is microbiome modulation rather than a single defined receptor interaction: after ingestion, the live organism is intended to transiently survive gastrointestinal passage, interact with intestinal epithelial and immune cells, and modulate mucosal and systemic immune responses. Based on the provided sources, this exact asset is best characterized as a strain-specific probiotic live microbial product/dietary supplement rather than a conventional pharmaceutical small molecule or biologic drug.
- Other names
- Lactobacillus acidophilus NCFML. acidophilus NCFM
02
Targets
Shigella spp. (Shigella species)MOR (Mu opioid receptor)
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