Drug intelligence / Profile preview

Lactobacillus brevis ProGA28

Development stage
Preclinical
Lead developer
Syngen Biotech
Modality
Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
Administration
Oral
01

Overview

Biojovial is a probiotic or postbiotic nutraceutical ingredient containing the bacterial strain *Lactobacillus brevis* ProGA28 (also classified as *Levilactobacillus brevis* ProGA28) or its metabolites, which naturally produce high levels of gamma-aminobutyric acid (GABA). Developed by Syngen Biotech, Biojovial is designed to improve sleep quality, promote relaxation, and attenuate stress-related sleep disturbances and anxiety-like behaviors through the modulation of the gut-brain axis and autonomic nervous system.

Brand names
Biojovial
Other names
L. brevis ProGA28Levilactobacillus brevis ProGA28Levilactobacillus brevis strain ProGA28
02

Targets

GABRR (GABA-A receptor subunit rho)GABA-B (Gamma-aminobutyric acid receptor type B)

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