Drug intelligence / Profile preview

lactobacillus complex JK-5G

Development stage: Unknown
Lead developer: Chongqing University Cancer Hospital
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Lactobacillus complex JK-5G is an investigational live biotherapeutic product consisting of a specific consortium of *Lactobacillus* strains. Developed by the Chongqing University Cancer Hospital, it is primarily being evaluated as an adjunctive therapy for patients with small cell lung cancer (SCLC). The drug's mechanism of action involves the modulation of the host's gut microbiota to stimulate systemic immune pathways and restore microbial homeostasis. This modulation is intended to enhance the anti-tumor efficacy of standard-of-care treatments, such as chemotherapy and immune checkpoint inhibitors, while potentially mitigating treatment-related gastrointestinal toxicities. As a microbiome-based intervention, JK-5G leverages the gut-lung axis to improve clinical outcomes in thoracic malignancies.

Other names: Lactobacillus complex JK-5G

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