Drug intelligence / Profile preview

lactobacillus-containing vaginal suppository

Development stage: Unknown
Lead developer: Agency for Medical Research and Development
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Vaginal

Overview

Lactobacillus-containing vaginal suppository is a live biotherapeutic product (LBP) designed to restore the healthy microbial balance of the female reproductive tract. It is primarily investigated for its ability to correct endometrial dysbiosis, a condition characterized by a lack of *Lactobacillus* species and an overgrowth of pathogenic bacteria, which is associated with chronic endometritis and recurrent implantation failure (RIF) in women undergoing assisted reproductive technology. By increasing the occupancy of *Lactobacillus* in the vaginal and endometrial environments, the suppository aims to reduce uterine inflammation and improve endometrial receptivity, thereby enhancing pregnancy and live birth rates. The development of this therapeutic approach is supported by clinical trials in Japan, including those funded by the Japan Agency for Medical Research and Development (AMED).

Other names: Lactobacillus vaginal suppositoryLVS

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