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Lactobacillus curvatus WiKim38
- Development stage
- Preclinical
- Lead developer
- Hankook Korus Pharm
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
HKP301 is a probiotic health functional food product being developed by Hankook Korus Pharm for the prevention of bone diseases, such as osteoporosis. The active ingredient is Lactobacillus curvatus WiKim38, a probiotic bacterial strain originally isolated from kimchi. The product's mechanism of action involves the inhibition of RANKL-induced osteoclast differentiation. Research has demonstrated that the cell-free culture supernatant of L. curvatus WiKim38 decreases the activation of the TRAF6/NF-κB/MAPKs signaling axis and reduces the expression of genes associated with osteoclastogenesis. In preclinical studies using ovariectomized mice, a model for postmenopausal osteoporosis, administration of the strain's culture supernatant was shown to increase bone volume and bone mineral density.
- Other names
- L. curvatus WiKim38
02
Targets
MEKNF-κBRANKL (Receptor Activator for Nuclear Factor-kappa B Ligand)TRAF6
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