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lactobacillus delbrueckii + lactobacillus rhamnosus
- Development stage
- Preclinical
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
A probiotic combination of Lactobacillus delbrueckii and Lactobacillus rhamnosus that acts as an immunomodulator, antimicrobial agent, and aids in cell growth and proliferation. This combination enhances production of anti-inflammatory cytokines (IL-10, TGF-β) while reducing pro-inflammatory cytokines (IL-12, IL-1β, TNF-α), suggesting polarization toward the M2 macrophage phenotype. It can significantly alter macrophages' capability to stimulate CD4+ T cells and has been studied for effects on autoimmune conditions.
02
Targets
TLR2 (Toll-like Receptor 2)
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