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lactobacillus fermentum + vitamin d3

Development stage
Phase 1
Lead developer
Essential Formulas
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Small Molecules, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral, Vaginal (for Lactobacillus Fermentum, As A Suppository Or Tablet)[4]
01

Overview

**lactobacillus fermentum + vitamin d3** is a combination of a probiotic, *Limosilactobacillus fermentum* (formerly known as *Lactobacillus fermentum*), and vitamin D3 (cholecalciferol). This combination is typically marketed as a dietary supplement and not as a pharmaceutical drug. The probiotic component supports gut health, influences the microbiome composition, and can modulate inflammatory responses. Vitamin D3 acts primarily as an immunomodulator, regulating calcium and phosphorus metabolism, and also modulates inflammatory cytokines. Evidence suggests synergistic benefits for immune, metabolic, and cognitive health, including reduced inflammation, improved epithelial barrier function, and enhanced physical performance, especially in certain populations such as athletes and those with specific diseases[3][5][6]. Studies show that combining vitamin D3 with probiotics (such as *Lactobacillus fermentum*) can improve the anti-inflammatory response, possibly by downregulating proinflammatory cytokines and improving gut epithelial cell permeability[1][5]. This combination is most commonly considered and used as a dietary supplement.

Other names
limosilactobacillus fermentum + cholecalciferol
02

Targets

VDR (Vitamin D receptor)

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