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Lactobacillus fermentum CQPC04
- Development stage
- Preclinical
- Lead developer
- The First People's Hospital of Kunshan
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
*Lactobacillus fermentum* CQPC04 is a specific probiotic bacterial strain originally isolated from traditional Sichuan pickles (Paocai). It is being researched for its potential therapeutic applications in metabolic disorders, particularly hyperlipidemia and hyperglycemia. The strain functions by modulating the gut microbiota and influencing systemic metabolic pathways. Research indicates that CQPC04 activates the AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1) signaling pathways, which in turn regulates the expression of genes involved in lipid metabolism, such as PPAR-α (Peroxisome proliferator-activated receptor alpha) and LXR-α (Liver X receptor alpha). In preclinical models, administration of this strain has been shown to significantly reduce total cholesterol, triglycerides, and blood glucose levels while improving antioxidant capacity and reducing inflammation. The development is primarily associated with research institutions in China, including The First People's Hospital of Kunshan and Chongqing University of Education.
- Other names
- L. fermentum CQPC04Lactobacillus fermentum strain CQPC04
02
Targets
PPARG (Peroxisome proliferator-activated receptor gamma)PPARA (Peroxisome proliferator-activated receptor alpha)PRKAA1 (AMP-activated protein kinase alpha catalytic subunit isoform alpha-1)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)SLC2A4 (Solute carrier family 2 facilitated glucose transporter member 4)
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