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lactobacillus gasseri DSM 27123
- Development stage
- Phase 2
- Lead developer
- BioGaia
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lactobacillus gasseri DSM 27123 (also known by the code name BGP345A) is a specific probiotic bacterial strain developed by BioGaia. It is being evaluated as a live biotherapeutic product for the treatment of opioid-induced constipation (OIC) in patients with chronic non-cancer pain. The strain is intended to restore healthy gut microbial balance and enhance intestinal transit, addressing the side effects of long-term opioid therapy on the digestive system. As a probiotic, it is designed to modulate the gut microbiota and potentially influence intestinal motility and secretomotor function to alleviate constipation symptoms.
- Other names
- L. gasseri DSM 27123
02
Targets
TRPV1 (Transient receptor potential cation channel subfamily V member 1)
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