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lactobacillus lactis lysate

Development stage: Discontinued
Lead developer: CLR Berlin
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Topical

Overview

Lactobacillus lactis lysate is a preparation made from the probiotic bacterium Lactobacillus lactis, where the bacterial cells have been broken down. It is considered a postbiotic and has been investigated as a topical, microbiome-targeted treatment for skin conditions. A clinical trial (EudraCT 2020-000514-15) evaluated its use in a cream for mild-to-moderate atopic dermatitis. [2] While the cream was found to be well-tolerated, it did not show significant efficacy in improving the signs and symptoms of atopic dermatitis compared to a placebo in a small pilot study. [2, 4, 5] The proposed mechanism involves modulating the skin's microbiome and immune responses to enhance skin barrier function, reduce inflammation, and provide a soothing effect. [3, 7, 8]

Other names: Lactobacillus ferment lysatePostbiotic Ferment Lysate

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