Drug intelligence / Profile preview

lactobacillus murinus

Development stage: Preclinical
Modality: Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
Administration: Oral

Overview

*Lactobacillus murinus* is a commensal Gram-positive bacterial species typically found in the gastrointestinal tract of rodents and other mammals. In the context of therapeutic research, it is classified as a live biotherapeutic product (LBP) or probiotic. It is being investigated for its ability to modulate the host immune system and maintain intestinal barrier integrity. Research indicates that *L. murinus* can metabolize dietary components into bioactive molecules such as indole-3-acetaldehyde (IAAld). These metabolites act as ligands for the aryl hydrocarbon receptor (AhR) and influence macrophage polarization, shifting them toward an anti-inflammatory phenotype. This process subsequently inhibits pro-inflammatory signaling pathways, including NF-κB and TGF-β, thereby attenuating conditions like sepsis-induced acute intestinal injury and systemic inflammation.

Other names: L. murinus

Targets

AHR (Aryl hydrocarbon receptor)NF-κB

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