Drug intelligence / Profile preview

Lactobacillus paracasei CBA L74

Development stage
Unknown
Lead developer
Kraft Heinz
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

Lactobacillus paracasei CBA L74 is a specific probiotic bacterial strain that has been developed in a **heat-killed/postbiotic fermented food formulation**, including fermented rice flour for oral use in infants. In the provided public clinical-publication context, it was studied as an adjunct to topical therapy for **atopic dermatitis** in infants aged 6-36 months. The reported study found no significant improvement in SCORAD versus placebo over 12 weeks, but did observe a **topical steroid-sparing effect**, while gut microbiota composition and serum cytokines were not significantly different between groups. The product is best characterized as a microbiome-related nutritional/postbiotic intervention rather than a conventional pharmaceutical drug; its proposed activity is host immune and barrier modulation through exposure to bacterial components and fermentation-derived metabolites rather than direct engagement of a single defined molecular target.

Other names
Lactobacillus paracasei CBA L74heat-killed Lactobacillus paracasei CBA L74fermented rice flour obtained from Lactobacillus paracasei CBA L74

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