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lactobacillus paracasei GMNL-133

Development stage: Preclinical
Lead developer: GenMont Biotech
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Lactobacillus paracasei GMNL-133 is a specific probiotic bacterial strain isolated for its potential health benefits. It belongs to the species Lactobacillus (now reclassified as Lacticaseibacillus) paracasei and is used primarily as a live biotherapeutic product in dietary supplements and functional foods. The mechanism of action involves modulation of the host microbiome, enhancement of gut barrier function, competitive inhibition of pathogenic bacteria, and immunomodulatory effects that may help reduce allergic responses such as those seen in atopic dermatitis or other allergic diseases[2][3]. This strain has been studied for its efficacy in treating atopic dermatitis and other allergic conditions.

Other names: lacticaseibacillus paracasei GMNL-133

Targets

PRR (Pattern recognition receptors)

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