Drug intelligence / Profile preview

lactobacillus paracasei NTU 101

Development stage
Phase 4
Lead developer
SunWay Biotech
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

Lactobacillus paracasei NTU 101 is a specific probiotic strain originally isolated from the intestines of healthy, breast-fed infants. [1, 5] It was developed by Professor Tzu-Ming Pan's research team at National Taiwan University, and the technology was exclusively authorized to SunWay Biotech Co., Ltd. for commercialization. [1, 9] The strain is marketed under the brand name Vigiis 101-LAB. [1] It has received Generally Recognized As Safe (GRAS) status from the U.S. FDA (GRN 001232). [4] Numerous studies have demonstrated its high tolerance to gastric acid and bile salts, allowing it to survive passage through the gastrointestinal tract. [1, 5] Its proposed mechanisms of action include modulating the gut microbiota, enhancing gut barrier function, and regulating the immune system. [3, 8, 10] Specifically, it has been shown to increase beneficial bacteria like Bifidobacterium and Lactobacillus, improve intestinal peristalsis, and balance the T-helper (Th1/Th2) cell response. [2, 4, 14] Clinical and preclinical studies suggest benefits for digestive health, atopic dermatitis, immune support, and managing metabolic conditions like obesity and high cholesterol. [2, 3, 6, 10]

Brand names
Vigiis 101-LABVigiis101-LABVigiis-101-LAB
Other names
Lacticaseibacillus paracasei subsp. paracasei NTU 101Lactobacillus paracasei subsp. paracasei NTU 101

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