Drug intelligence / Profile preview

Lactobacillus paracasei PC-01

Development stage
Unknown
Lead developer
Mengniu
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

Lactobacillus paracasei PC-01 is a specific probiotic strain belonging to the Lacticaseibacillus paracasei species, primarily investigated for its therapeutic potential in gastrointestinal disorders. Developed and studied by researchers at the West China School of Public Health, Sichuan University, in collaboration with By-Health Co., Ltd., it is being evaluated as a live biotherapeutic product for the treatment of functional dyspepsia (FD). The strain is thought to exert its effects by modulating the gut microbiota composition, enhancing intestinal barrier integrity, and potentially influencing the gut-brain axis to improve gastric motility and reduce visceral hypersensitivity. Clinical evidence from randomized, double-blind, placebo-controlled trials suggests that oral administration of PC-01 can significantly alleviate symptoms of functional dyspepsia, including postprandial fullness and epigastric pain, thereby improving the quality of life for affected patients.

Other names
L. paracasei PC-01Lacticaseibacillus paracasei PC-01

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