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Drug intelligence / Profile preview
Lactobacillus pentosus GMNL-77
- Development stage
- Preclinical
- Lead developer
- GenMont Biotech
- Modality
- Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lactobacillus pentosus GMNL-77 is a specific probiotic bacterial strain developed by GenMont Biotech. It is being investigated for its immunomodulatory properties, particularly in the treatment of chronic inflammatory skin conditions such as psoriasis. The strain functions by modulating the gut-skin axis, leading to a systemic reduction in proinflammatory cytokines. Preclinical studies have demonstrated that oral administration of GMNL-77 can significantly decrease erythematous scaling and epidermal hyperplasia by downregulating the interleukin (IL)-23/IL-17A cytokine axis. It also reduces levels of tumor necrosis factor-alpha (TNF-alpha), IL-6, and IL-22, while decreasing the infiltration and activity of IL-17-producing T cells.
- Other names
- L. pentosus GMNL-77Lactobacillus pentosus strain GMNL-77
02
Targets
IL-17A (Interleukin-17A)IL22 (Interleukin 22)IL-23 (Interleukin-23)IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))
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