lactobacillus plantarum

Lactobacillus plantarum is a probiotic bacterial species used as a live microbial therapeutic or supplement rather than a single chemically defined pharmaceutical ingredient. In the provided sources, it appears as a non-strain-specific drug name that encompasses multiple distinct clinical products and investigational preparations, including strains such as Lp05, L168, GL-5, LZU-J-TSL6, CCFM8610, CCFM8610-containing preparations, N13, and NCIMB8826-related research use. Its proposed mechanism is microbiome modulation: oral administration can alter gut community composition, increase colonization resistance against pathogenic organisms, improve epithelial barrier integrity, reduce bacterial translocation, generate antimicrobial metabolites and other bioactive products, and modulate host innate and adaptive immune responses. Clinical and translational studies cited in the source material link Lactobacillus plantarum preparations to development or investigation in gastrointestinal disorders, neonatal sepsis prevention, metabolic disease, neurobehavioral disorders, perioperative care, dermatologic disease, and immune modulation; however, because efficacy and safety are strain-specific, the exact activity, developer, formulation, and regulatory status depend on the individual strain product rather than the species name alone.

Brand names

VSL#3

Other names

Lactobacillus plantarum植物乳杆菌Lactiplantibacillus plantarum