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Lactobacillus plantarum A87

Development stage
Unknown
Lead developer
Athelas B&P
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

*Lactobacillus plantarum* A87 is a specific probiotic bacterial strain belonging to the species *Lactiplantibacillus plantarum* (formerly *Lactobacillus plantarum*). It is primarily developed and investigated for its metabolic health benefits, particularly in the management of obesity and related metabolic disorders. The strain exerts its therapeutic effects through the modulation of the gut microbiota and the regulation of host lipid metabolism. Research indicates that A87 can suppress the expression of key adipogenic transcription factors, including peroxisome proliferator-activated receptor gamma (PPAR-gamma) and CCAAT/enhancer-binding protein alpha (C/EBP-alpha), thereby inhibiting adipocyte differentiation and fat accumulation. Additionally, it has been observed to reduce systemic inflammation and improve glucose tolerance in preclinical models and human clinical trials. It is typically commercialized as a functional food ingredient or a dietary supplement for weight management.

Brand names
A87 ProbioticsA-87 ProbioticsA 87 Probiotics
Other names
Lactiplantibacillus plantarum A87L. plantarum A87
02

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)CEBPA (CCAAT enhancer-binding protein alpha)

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