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lactobacillus plantarum ccfm8610
- Development stage
- Preclinical
- Lead developer
- Jiangnan University
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lactobacillus plantarum CCFM8610 is a specific probiotic strain developed by researchers at Jiangnan University and marketed under brands like HelpGut®. [11, 18] It is being investigated for several therapeutic applications. A clinical trial showed that in patients with atopic dermatitis, it can reduce disease severity (SCORAD index), modulate the immune system by increasing anti-inflammatory cytokine IL-10 levels, and beneficially alter the gut microbiota composition. [14] It is also being studied for its potential to inhibit Helicobacter pylori infection. Additionally, preclinical and clinical studies have demonstrated its ability to protect against cadmium toxicity by binding the heavy metal in the intestine, reducing its absorption and tissue accumulation, and mitigating oxidative stress. [14, 19]
- Brand names
- HelpGut
- Other names
- 植物乳杆菌CCFM8610
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