lactobacillus plantarum ccfm8724

Lactobacillus plantarum CCFM8724 is a specific probiotic strain being investigated for its potential to prevent and treat dental caries, particularly Early Childhood Caries (ECC). A randomized, double-blind, placebo-controlled clinical trial in children demonstrated that this strain significantly reduces the oral populations of key cariogenic pathogens, *Streptococcus mutans* and *Candida albicans*. Originally isolated from healthy human feces, its mechanism of action involves disrupting the formation of mixed-species biofilms created by these pathogens. It achieves this by interfering with the pathogens' sugar metabolism, glucan biosynthesis, and mycelium formation, thereby reprogramming the biofilm's gene expression and metabolism. Studies in rat models also confirmed its ability to decrease oral pathogen populations, reduce enamel mineral loss, and lower caries scores, with some research suggesting its effects were superior to chlorhexidine. Research has also identified specific bioactive compounds it produces, such as cyclo (leu-pro) and hydrocinnamic acid, which possess anti-biofilm activity. The strain was developed and is primarily researched by scientists at Jiangnan University.

Other names

Lactiplantibacillus plantarum CCFM8724