Drug intelligence / Profile preview

Lactobacillus plantarum LP1

Development stage
Unknown
Lead developer
Probiotical
Modality
Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

Lactobacillus plantarum LP1, also known as LP01, is a specific strain of the probiotic bacterium Lactiplantibacillus plantarum. It is widely studied and utilized as a dietary supplement and nutraceutical for its various health benefits, particularly in supporting gastrointestinal health. The mechanism of action for L. plantarum LP1 involves multiple pathways: it helps maintain a healthy gut microbiota by competitively inhibiting the growth of pathogenic bacteria through the production of antimicrobial substances like lactic acid. It also enhances the gut barrier function, modulates the immune system by interacting with gut-associated lymphoid tissue (GALT), and aids in the fermentation of undigested carbohydrates to produce beneficial short-chain fatty acids (SCFAs). As a probiotic, it is not absorbed into the bloodstream but colonizes the gastrointestinal tract before being excreted. It has been investigated for managing conditions such as irritable bowel syndrome (IBS), constipation, and for mitigating intestinal symptoms following procedures like colonoscopy.

Brand names
AbincolBifivirFlor-en AdultsAllerfloraBificolProbial StomachActivagProbial AgeBifizenAlitolactisBificistBifiprostProbial ASDProbial Flat Belly
Other names
Lactiplantibacillus plantarum LP01
02

Targets

STING (Stimulator of interferon genes protein)TLR2 (Toll-like Receptor 2)

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