lactobacillus plantarum LPL28

**Lactobacillus plantarum LPL28** is a specific probiotic strain of Lactobacillus plantarum, originally isolated from fermenting soybeans in 2011[3]. It is characterized by its beneficial effects on oral health, notably in reducing *Streptococcus mutans*, improving oral microbial flora, increasing secretory IgA in saliva, and supporting the immune response[3][4][6]. LPL28 is distinguished for its strong tolerance to acidic and bile environments, indicating robust survivability through the gastrointestinal tract[3]. Clinical research highlights its applications as a food additive and in oral lozenge formulations to promote oral health, relieve gastrointestinal symptoms, and decrease the incidence of oral infections, constipation, gastroesophageal reflux, and upper respiratory tract symptoms[2][4][6]. The strain has demonstrated superior antipathogenic and bactericidal activities against major oral pathogens (*S. mutans*, *A. actinomycetemcomitans*, *P. gingivalis*) in both postbiotic (heat-killed and fermentation product) and viable forms[2]. Its mechanism of action involves microbiome modulation, pathogen inhibition by antimicrobial metabolite production, and immunostimulation.

Other names

LPL28LPL-28LPL 28L. plantarum LPL28