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lactobacillus probiotic mix
- Development stage
- Preclinical
- Lead developer
- Virginia Tech
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
The lactobacillus probiotic mix is a specific formulation consisting of five distinct strains of the *Lactobacillaceae* family. It has been investigated in preclinical research for its potential to treat systemic lupus erythematosus (SLE). In studies using lupus-prone MRL/lpr mice, the mix was shown to restore gut microbiota balance and significantly attenuate autoimmune symptoms, including splenomegaly, lymphadenopathy, and proteinuria. Its mechanism of action involves the reversal of intestinal permeability (leaky gut), which prevents the translocation of commensal bacteria into the mesenteric lymph nodes and downregulates serum endotoxin levels. The therapeutic benefits of this probiotic mix are also linked to the modulation of systemic inflammation, particularly through interactions with CX3CR1+ macrophages.
- Other names
- 5-strain Lactobacillus mixprobiotic lactobacilli mix
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