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lactobacillus reuteri BGP-014
- Development stage
- Phase 2
- Lead developer
- BioGaia
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lactobacillus reuteri BGP-014 is an investigational oral live biotherapeutic product (LBP) being developed by BioGaia Pharma AB for the treatment of mild to moderate active ulcerative colitis (UC). The active ingredient is a specific strain of the bacterium *Lactobacillus reuteri*, designated BGP-014, which is formulated into oral capsules. It is intended for use as an adjunctive therapy alongside standard treatments such as aminosalicylates or corticosteroids. The proposed mechanism of action involves the modulation of gut mucosal immunity, the reduction of pro-inflammatory cytokine production, and the restoration of intestinal barrier integrity. BGP-014 is currently undergoing Phase 1 clinical evaluation to assess its safety, tolerability, and exploratory efficacy in patients with active UC.
- Other names
- Lactobacillus reuteri BGP-014L. reuteri BGP-014
02
Targets
PRR (Pattern recognition receptors)HRH2 (Histamine H2 Receptor)ADORA2A/ADORA2B (Adenosine A2A and A2B receptors)AHR (Aryl hydrocarbon receptor)
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