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Lactobacillus reuteri SLG01
- Development stage
- Preclinical
- Lead developer
- Centro Odontoiatrico Mediterraneo
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral, Topical
01
Overview
Lactobacillus reuteri SLG01 is a probiotic bacterial strain under development for the prevention of dental caries. In preclinical studies, a formulation containing L. reuteri SLG01, vitamin C, and acerola demonstrated bactericidal and antibiofilm activity against Streptococcus mutans, a primary cariogenic pathogen. The strain's cell-free supernatant (CFS) exhibits rapid bactericidal kinetics, significantly reducing S. mutans viability and impairing biofilm formation. It is being investigated as a non-antibiotic, preventive adjunct to maintain oral health and prevent dysbiosis of the oral microbiome.
- Other names
- L. reuteri SLG01
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