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Drug intelligence / Profile preview
lactobacillus rhamnosus-derived extracellular vesicles
- Development stage
- Preclinical
- Lead developer
- Ocean University of China
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Oral, Rectal, Intravenous
01
Overview
Lactobacillus rhamnosus-derived extracellular vesicles (LGG-EVs) are nanoparticles released by the probiotic bacterium *Lactobacillus rhamnosus* GG. They are being investigated for their therapeutic potential in inflammatory conditions, particularly inflammatory bowel disease (IBD) such as ulcerative colitis. [1, 9] Preclinical studies in mice with DSS-induced colitis have shown that LGG-EVs can reduce intestinal inflammation and tissue damage. [1, 4] The proposed mechanism of action involves the inhibition of the TLR4-NF-κB-NLRP3 signaling pathway, which leads to a decrease in pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6. [1, 2, 3] Additionally, LGG-EVs have been observed to modulate the gut microbiota, restoring a healthier composition in diseased models. [1, 3]
- Brand names
- LGG-EVs
- Other names
- Lactobacillus rhamnosus GG derived extracellular vesiclesL. rhamnosus GG-EVs
02
Targets
NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)TLR4 (Toll-like receptor 4)NF-κB
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