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Lactobacillus rhamnosus GG + Bifidobacterium animalis subsp. lactis BB-12 (Sheppard Pratt)
- Development stage
- Unknown
- Lead developer
- Novonesis
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
An investigational probiotic supplement comprising two bacterial strains, *Lactobacillus rhamnosus* LGG® and *Bifidobacterium animalis subsp. lactis* BB-12®, being developed and studied by Sheppard Pratt Health System for psychiatric disorders. It is currently in a Phase 2 clinical trial for the prevention of relapse in individuals recently hospitalized for bipolar depression. [2, 3] The proposed mechanism of action involves modulating the gut-brain axis and reducing gut inflammation, which is believed to be a contributing factor in the symptoms of bipolar disorder. [4, 5] Previous research by the same team indicated that this probiotic combination was effective in reducing rehospitalization rates for patients with acute mania. [6, 8]
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