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Drug intelligence / Profile preview
lactobacillus rhamnosus GG cell extract
- Development stage
- Preclinical
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Lactobacillus rhamnosus GG (LGG) cell extract is a postbiotic preparation derived from the standard probiotic strain *Lacticaseibacillus rhamnosus* GG. It is being investigated as a complementary anticancer therapy, particularly for colorectal cancer. Research indicates that the extract, containing bacterial metabolites and cellular components, can selectively induce apoptosis and decrease viability in human colon cancer cell lines (such as HT-29) while providing a cytoprotective effect on normal cells (such as HEK-293) against chemotherapy-induced toxicity. When used in combination with 5-fluorouracil (5-FU), the extract appears to enhance anti-tumor immunity by stimulating the production of Th17-related cytokines, including IL-17A, IFN-γ, and TNF-α.
- Other names
- LGG cell extractLacticaseibacillus rhamnosus GG cell extractLactobacillus rhamnosus GG extract
02
Targets
IFNG (Interferon gamma)IL-17A (Interleukin-17A)TNFA (Tumor necrosis factor alpha (soluble))
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