Drug intelligence / Profile preview

Lactobacillus rhamnosus R7970

Development stage
Unknown
Modality
Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
Administration
Oral
01

Overview

Lactobacillus rhamnosus R7970 is a specific probiotic bacterial strain belonging to the species *Lactobacillus rhamnosus* (also known as *Lacticaseibacillus rhamnosus*). This strain has demonstrated several beneficial effects in clinical and preclinical studies. It is notable for its ability to modulate intestinal microbiota, enhance digestive function, and improve immune responses. Mechanistically, it acts by inhibiting pathogenic bacteria (including both bacteria and fungi), reducing inflammation in the gut, and supporting mucosal barrier integrity. Key applications of Lactobacillus rhamnosus R7970 include: - Prevention and relief of gastrointestinal discomfort following mechanical injury such as colonoscopy (reducing symptoms like abdominal pain, diarrhea, bloating, indigestion, and rectal bleeding)[3]. - Prevention or treatment of infectious diseases caused by pathogenic bacteria or fungi—including oral pathogens—due to its broad-spectrum antimicrobial activity[6]. - Potential prevention of inflammatory bowel disease (IBD) through anti-inflammatory effects on the gut[4]. The strain is recognized for its safety profile; it does not exhibit hemolytic activity in standard tests[6] and shows sensitivity to most antibiotics except vancomycin. It can be used alone or combined with vancomycin for enhanced infection control.

Other names
鼠李糖乳杆菌R7970Lacticaseibacillus rhamnosus R7970
02

Targets

Intestinal mucins and glycocalyx

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