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Lactobacillus salivarius PS7 is a probiotic bacterial strain investigated for its potential to prevent recurrent acute otitis media (AOM) in children. As a live biotherapeutic, it is intended to colonize the upper respiratory tract and nasopharynx, where it may inhibit the growth and colonization of common otopathogens through competitive exclusion, production of antimicrobial compounds, and modulation of the local immune response. The strain was evaluated in the PROMAR clinical trial, a randomized, double-blind, placebo-controlled study designed to assess its efficacy in reducing the frequency of AOM episodes over a six-month administration period.
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