Drug intelligence / Profile preview

lactobacillus vaginalis

Development stage
Unknown
Lead developer
Jiangsu Provincial People's Hospital
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Vaginal
01

Overview

Lactobacillus vaginalis refers to a live biotherapeutic preparation, typically administered as vaginal capsules, containing viable *Lactobacillus* species intended to restore or maintain a healthy vaginal microbiota. In the context of clinical research conducted by Shanghai General Hospital, it is being investigated as an adjuvant therapy alongside dydrogesterone and metformin for the treatment of endometrial hyperplasia (EH). The rationale for this intervention is based on the hypothesis that the vaginal and uterine microbiota influence endometrial health and that restoring a *Lactobacillus*-dominant environment may improve the complete remission (CR) rate of the endometrium by modulating local inflammation or metabolic pathways. While the name is used in clinical trial registries, it likely refers to a generic or specific probiotic product containing common vaginal species such as *L. crispatus* or *L. acidophilus* rather than a single taxonomically distinct species named *L. vaginalis*.

Other names
vaginal lactobacillusvaginal lactobacillus viable capsules

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