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lactoferrin + berberine + hyaluronic acid + silk fibroin
- Development stage
- Unknown
- Modality
- Small Molecules, Recombinant Proteins and Enzymes, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
01
Overview
A **multi-component nanoformulation** comprising lactoferrin, berberine, hyaluronic acid, and silk fibroin. Based on the provided context, this is best understood as an experimental **nanoparticle or biomaterial-based drug delivery construct** rather than an approved named drug product. Berberine is the cytotoxic small-molecule payload, while hyaluronic acid and lactoferrin are used as bioactive targeting and delivery components; silk fibroin functions as a structural biomaterial carrier. Mechanistically, the construct is intended to improve tumor-selective delivery and retention, with hyaluronic acid commonly used to engage CD44-enriched tumor cells, lactoferrin serving as a targeting and uptake-enhancing protein, and berberine providing anticancer activity through pleiotropic effects on proliferation and apoptosis pathways. No specific sponsor, brand name, or formal development program for the exact four-component combination was identified from the provided source excerpt.
- Other names
- lactoferrin + berberine + hyaluronic acid + silk fibroinLf + berberine + hyaluronic acid + silk fibroinLf/BER-HA-silk fibroin
02
Targets
CD44 (CD44 antigen)
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