Drug intelligence / Profile preview

Lactogyn

Development stage: Unknown
Lead developer: Pharmextracta
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Lactogyn is a probiotic combination product developed by Vésale Pharma, containing three specific strains of beneficial bacteria: *Lactobacillus crispatus* (strain LMG S-29995), *Lactobacillus brevis*, and *Lactobacillus acidophilus*. Formulated as an oral capsule, it is designed to restore and maintain a healthy vaginal microbiota, particularly in women treated for bacterial vaginosis (BV). The mechanism of action involves the colonization of the vaginal environment by these Lactobacillus species, which produce lactic acid and hydrogen peroxide. This process helps maintain a low vaginal pH, thereby inhibiting the growth of pathogenic bacteria and reducing the recurrence rate of BV. Clinical evidence from a Phase 2 randomized placebo-controlled trial demonstrated that oral administration of this combination significantly decreased the recurrence of bacterial vaginosis over a four-month period.

Brand names: Lactogyn
Other names: lactobacillus crispatus + lactobacillus brevis + lactobacillus acidophilus

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