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Ladybiome
- Development stage
- Unknown
- Lead developer
- Nexbiome Therapeutics
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Topical
01
Overview
Ladybiome (NBT-02) is a live biotherapeutic product (LBP) being developed by Nexbiome Therapeutics for the treatment of vaginal infections, including bacterial vaginosis and vulvovaginal candidiasis. The therapy utilizes specific beneficial bacterial strains, likely from the *Lactobacillus* genus, to restore a healthy vaginal microbiome balance. By replenishing commensal bacteria, Ladybiome aims to lower vaginal pH through lactic acid production and inhibit the overgrowth of pathogenic organisms via competitive exclusion and the production of antimicrobial substances. It is currently in Phase 1/2 clinical development, representing a microbiome-targeted approach to managing recurrent vaginal dysbiosis.
- Brand names
- Ladybiome
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