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laggera pterodonta mixture
- Development stage
- Phase 4
- Lead developer
- Second Affiliated Hospital of Kunming Medical University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Laggera pterodonta mixture is a botanical drug preparation derived from the plant *Laggera pterodonta* (Benth.) Benth. ex Oliv., a species widely used in Traditional Chinese Medicine under the name Chou Ling Dan. The mixture is primarily indicated for the treatment of respiratory tract infections due to its potent anti-inflammatory, anti-viral, and anti-bacterial activities. Its therapeutic effects are attributed to bioactive constituents such as sesquiterpenoids and flavonoids, which modulate the immune response by inhibiting the release of pro-inflammatory cytokines like TNF-α and IL-6 and suppressing the NF-κB signaling pathway. Clinical evaluation has focused on its efficacy and safety in pediatric patients, particularly for acute bronchiolitis in children aged 24 months and younger.
- Brand names
- Chou Ling Dan Heji
- Other names
- Chou Ling Dan mixtureLaggera pterodonta (Benth.) Benth. ex Oliv. mixture
02
Targets
IL-6 (Interleukin 6)NF-κBTNFA (Tumor necrosis factor alpha (soluble))
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