laherradurin

Laherradurin is a naturally occurring **acetogenin** isolated from *Annona macroprophyllata* that has been investigated preclinically as an anticancer agent, particularly in colorectal cancer. In the cited murine azoxymethane dextran sulfate sodium colorectal cancer model, laherradurin reduced tumor number and size, showed evidence of apoptosis induction, inhibited migration of HCT116 colon cancer cells in vitro, and appeared less toxic than cisplatin in that study. Its precise molecular target and mechanism of action have not been definitively established from the provided evidence, so it is best described as a natural product small molecule with experimental antineoplastic activity rather than a clinically developed targeted therapy.

Other names

laherradurinLH