LAMA3 siRNA

LAMA3 siRNA is a small interfering RNA (siRNA) molecule designed to specifically silence the expression of the LAMA3 gene, which encodes the laminin subunit alpha 3, a component of extracellular matrix proteins critical for basement membrane structure, cell adhesion, proliferation, and migration. LAMA3 siRNA mediates post-transcriptional gene silencing by targeting LAMA3 mRNA, leading to its degradation and reduced LAMA3 protein production. Experimental studies, particularly in cholangiocarcinoma (CCA) cell lines, demonstrate that LAMA3 siRNA efficiently downregulates LAMA3A mRNA, resulting in reduced cancer cell proliferation, inhibition of cell adhesion and migration, and reversion of epithelial-to-mesenchymal transition (EMT) phenotypes. These findings suggest that LAMA3 siRNA has potential therapeutic value as an investigational cancer therapy and as a tool for functional genomics research[1][2][3][6][9][11].

Other names

LAMA3 siRNALAMA-3 siRNALAMA 3 siRNA