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lamivudine + ursolic acid
- Development stage
- Preclinical
- Modality
- Small Molecules, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Oral, Intravenous
01
Overview
LMX is an experimental codrug and liposomal formulation that combines the antiviral nucleoside analog lamivudine with the pentacyclic triterpenoid ursolic acid. It is designed for the treatment of Hepatitis B Virus (HBV) infection, aiming to provide a dual therapeutic effect: lamivudine acts as a potent inhibitor of HBV DNA polymerase/reverse transcriptase to suppress viral replication, while ursolic acid provides hepatoprotective and anti-inflammatory benefits to mitigate acute liver injury. The compound is typically formulated in liposomal preparations to enhance the bioavailability and liver-targeting efficiency of the two active moieties. Research has explored its administration via both oral and intravenous routes to optimize therapeutic outcomes in chronic hepatitis B management.
- Other names
- Lamivudine-ursolic acid codrugLMX liposomes
02
Targets
HBV Pol (Hepatitis B virus polymerase)
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