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Lanconone
- Development stage
- Unknown
- Lead developer
- Enovate Biolife
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Lanconone (E-OA-07) is a standardized botanical dietary supplement developed by Enovate Biolife for the management of chronic joint pain and osteoarthritis. The formulation is a unique combination of extracts from seven Ayurvedic herbs: *Commiphora mukul*, *Boswellia serrata*, *Withania somnifera*, *Oroxylum indicum*, *Smilax china*, *Pluchea lanceolata*, and *Zingiber officinale*. It acts as a multi-target anti-inflammatory agent, inhibiting key mediators of joint degradation and pain, including cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1beta). Clinical studies have demonstrated that Lanconone significantly reduces pain and stiffness while improving physical function in patients with knee osteoarthritis, often showing a rapid onset of action and a favorable safety profile compared to conventional non-steroidal anti-inflammatory drugs (NSAIDs).
- Brand names
- Lanconone
- Other names
- E-OA-07E-OA07E-OA 07
02
Targets
ALOX12 (Arachidonate 12-lipoxygenase, 12S type)ALOX5 (Arachidonate 5-lipoxygenase)IL1B (Interleukin-1 beta)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TNFA (Tumor necrosis factor alpha (soluble))
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