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Drug intelligence / Profile preview
lanreotide + temozolomide
- Development stage
- Phase 2
- Lead developer
- Ipsen
- Modality
- Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules, Peptides
- Administration
- Oral, Subcutaneous
01
Overview
Lanreotide + temozolomide is a combination therapy used primarily for the treatment of progressive neuroendocrine tumors, including gastroenteropancreatic and thoracic neuroendocrine tumors. Lanreotide is a synthetic somatostatin analog that acts mainly via somatostatin receptor subtypes 2 and 5, inhibiting hormone secretion and exerting antiproliferative effects on tumor cells. Temozolomide is an oral alkylating agent of the triazene class that methylates DNA at several sites, leading to cell cycle arrest and apoptosis in rapidly dividing tumor cells. The combination has shown efficacy in patients with advanced or metastatic well-differentiated neuroendocrine tumors who have progressed on other therapies, with a manageable safety profile[1][2][3][5].
- Brand names
- Somatuline Depot (lanreotide)
- Other names
- LANTMZ
02
Targets
DNASSTR2 (Somatostatin receptor type 2)SSTR5 (Somatostatin receptor 5)
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