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lansoprazole + naproxen
- Development stage
- Unknown
- Lead developer
- Takeda
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a **combination drug** containing two active pharmaceutical ingredients: **lansoprazole**, a proton pump inhibitor (PPI), and **naproxen**, a nonsteroidal anti-inflammatory drug (NSAID). Lansoprazole decreases gastric acid production by inhibiting the H+/K+ ATPase in gastric parietal cells, protecting the gastric mucosa from NSAID-induced ulcers. Naproxen acts by inhibiting the cyclooxygenase (COX-1 and COX-2) enzymes, reducing the synthesis of prostaglandins and thereby decreasing inflammation, pain, and fever. This fixed-dose combination is primarily indicated to treat **osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis** in patients at risk of NSAID-induced gastric ulcers, combining anti-inflammatory efficacy with gastroprotection[1][2][3][4][6][7].
- Brand names
- Prevacid NapraPAC 375Prevacid NapraPAC 500
- Other names
- lansoprazole and naproxennaproxen-lansoprazoleNapraPAC
02
Targets
VRAC (Volume-regulated anion channel protein LRRC8A)PGHS-1 (Prostaglandin G/H Synthase 1)ATP4A (Potassium–transporting ATPase alpha chain 1)
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