lanthanum hydroxide

Lanthanum hydroxide is an inorganic compound (La(OH)₃) investigated as a **phosphate binder** for the control of hyperphosphatemia, primarily in the context of chronic kidney disease (CKD) and renal failure. It works by binding dietary phosphate in the gastrointestinal tract, reducing absorption and lowering serum phosphate levels. Recent animal studies indicate additional pharmacological effects, such as protecting renal function, postponing development of renal failure, and mitigating vascular calcification by **inhibiting the nuclear factor kappa-B (NF-κB) signaling pathway** and the **receptor activator for nuclear factor-κB ligand/osteoprotegerin (RANKL/OPG) signaling cascade**. Compared to other phosphate binders, lanthanum hydroxide is notable for its effectiveness in reducing blood phosphate, and it does not affect fat-soluble vitamin absorption.

Other names

lanthanum(III) hydroxide