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lanthanum polystyrene sulfonate
- Development stage
- Phase 2
- Lead developer
- Shandong Penglai Nuokang Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Lanthanum polystyrene sulfonate is a **small molecule drug** under development as a **phosphate binder** for the treatment of **hyperphosphatemia** primarily in patients with end-stage renal disease undergoing hemodialysis. It acts via cation exchange, binding phosphate ions in the gastrointestinal tract to reduce serum phosphate levels. Its mechanism is distinct from classic potassium binders, utilizing the lanthanum ion integrated into polystyrene sulfonate resin. The drug is not absorbed systemically and exerts its effect via sequestration and removal of phosphate ions through fecal excretion. Clinical data includes phase 1/2 studies in patients with end-stage renal disease and hyperphosphatemia[1].
- Other names
- polystyrene sulfonic lanthanum聚苯乙烯磺酸镧散
02
Targets
Pi (Inorganic phosphate)
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